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WHY IS METHYLATION SO IMPORTANT? AND HOW DOES FOLIC ACID ASSIST?

Updated: Dec 1, 2021

The topic of methylation is a common one in the functional medicine community. But what is methylation? Simply put, methylation is a chemical reaction that occurs in every cell and tissue in your body.






Chemically speaking, methylation is the process of adding methyl groups to a molecule. A "methyl group" is a chemical structure made up of one carbon and three hydrogen atoms. Since methyl groups are chemically inert, adding them to a protein (the "methylation" process) changes the way that protein reacts to other substances in the body, thus affecting how that protein behaves. Enzymes, hormones, and even genes are proteins, and the "methylation" process affects them all.


In some cases, protein methylation helps the body detoxify. For example, the methylation process helps convert the toxic amino acid (homocysteine) into a beneficial amino acid (methionine). If your body cannot methylate properly, toxins build up in your bloodstream and will eventually cause illness.


Another role of methylation is to help our body's enzymes work efficiently. Enzymes are proteins that act as switches for chemical reactions: they initiate very important processes in every cell and tissue. Similarly, methylation affects our genes, which are also made up of proteins. In fact, methylation can turn genes on or off, which can be good or bad for our health, depending on the gene.


Some nutrients affect the methylation process quite dramatically: methyl donors (nutrients like folate and choline) actually donate methyl groups to proteins, and methylation factors (nutrients like vitamin B12 and zinc) help in this process by monitoring reactions of specific methylation. How well your body methylates is important to your overall health.


What is MTHFR and how is it related to methylation?


MTHFR (methyletetrahydrofolate reductase) is an enzyme that converts folate into a usable form that our bodies need. It is a key enzyme in an important detoxification reaction in the body, one that converts homocysteine (toxic) to methionine (benign). If the enzyme is altered, this detoxification reaction is impaired, leading to elevated levels of homocysteine in the blood. Homocysteine is abrasive to blood vessels, essentially scratching them, leaving damage that causes heart attacks, strokes, dementia, and a host of other problems.


MTHFR converts 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. It is 5-methyltetrahydrofolate that converts homocysteine to methionine through the enzyme methionine synthase. Homocysteine can also be converted to methionine by betaine-homocysteine methyltransferase. This enzyme does not require folic acid.


Furthermore, when the MTHFR enzyme is altered, other methylation reactions are compromised. Some of these methylation reactions affect neurotransmitters, which is why altered MTHFR activity is linked to depression. MTHFR enzyme inefficiency is also linked to migraines, autism, fertility, cancer, and birth defects, all of which depend on proper methylation.


What is the MTHFR gene?

The MTHFR gene encodes the MTHFR enzyme. There are variations in the gene that affect the function of the enzyme. This is explained in more detail below. A simple blood test can tell you if you have a variant copy of this gene.


If I have variant copies of the MTHFR gene, what can I do?

If the MTHFR enzyme is ineffective, it may be able to compensate for your body's inability to methylate efficiently, as this biological process relies on various B vitamins. You may simply need more B vitamins than someone without a variant copy of it. gene, such as vitamin B6, B12 (methylcobalamin) and the active form of folate (5-methyl tetrahydrofolate). Other methyl donors such as SAMe and trimethylglycine (TMG) may also provide benefits. If you have a faulty copy of the MTHFR gene, it is important to monitor your homocysteine ​​level as well. Fortunately, homocysteine ​​can often be lowered with the nutritional supplements listed above.


Determining which copies of the MTHFR gene you have gives you the ability to compensate accordingly. The old paradigm that we are simply at the mercy of our genes is now being challenged. Genetic testing lets you take control, launching you into a new era of truly individualized healthcare.


Here, the SOLUTION our group of Esteemed Scientists has successfully achieved in almost 40 years of research and development in the VERY SAFE AND VERY EFFECTIVE USE OF A HIGH DILUTION DERIVATIVE OF FOLIC ACID (METABOLITE) AND ITS "SPECIFICALLY PROGRAMMED PROTOCOLS" to modulate various acute, systemic and chronic diseases such as multiple sclerosis, cancers, cardiovascular and vascular diseases, HIV, fatty liver disease, depression, anemia, anxiety, high triglycerides, obesity, diabetes, rheumatoid arthritis, and many more chronic diseases.


We take the US FDA approved use of 5MG / ML administered intramuscularly and further dilute this 100X in a 100ML vial of sterile saline to create a 0.05MG / ML solution to be administered intramuscularly . This is done for the following reason:


There is a close connection between formic acid and THF (tedra-hydro-folic acid), including other very important metabolites such as glycine, serine, and methionine. There is NO life without these compounds. Therefore, the idea that folic acid is used only to attack or treat anemia is INCORRECT, but rather to treat the whole organism.


When one uses ONLY folic acid in relatively strong concentrations like 5MG / ML, then in our opinion, then this would be considered a treatment for a certain disorder, like anemia; This is called an "overwhelming treatment protocol," but when you use the same compound in very low doses or high dilutions, it means that it affects the entire body as a whole.


In our case, our "Therapeutic Modulator", by further diluting the amount of Folic Acid per ml, this would NOT be considered a treatment but a "MODULATION", A GENTLE ACTION FOR THE WHOLE BODY AND ALL ITS BIOLOGICAL SYSTEMS, GENERATING DEEP EFFECTS POSITIVE, NO POSSIBILITY OF NEGATIVE SIDE EFFECTS.


AND THIS VERY SAFE AND VERY EFFECTIVE MODULATOR THERAPEUTIC CREATES A STABLE METHYLATION ENVIRONMENT WHICH IS A FORM OF STABILIZATION AND GOOD HEALTH.


METHYLATION IS A FOUNDATION OF ALL METABOLIC PATHWAYS. DEMETILATION IS AGING AND DISEASE.

 
 
 

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